Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opsonophagocytic killing.The adenylate cyclase toxin (CyaA) of Bordetella pertussis and the edema toxin (ET) of Bacillus anthracis are both calmodulin-activated toxins with adenylyl cyclase activity that invade host cells and massively increase the cellul

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Research on the geological process of river action on the toppling deformation of rocky bank slopes in V-shaped gorge reservoirs

The toppling deformation in bank slope of V-shaped Gorge reservoirs in Southwest China is very common.After the impoundment of the reservoir, geological disasters such as collapse and landslide may occur in toppling bank slope, which poses a threat to the normal operation of hydropower projects and personnel safety.Therefore, it is of great enginee

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